For reasons not clearly explained, Team Coulson's hunt for Skye has led to them deciding they want to infiltrate Hydra... and to do this they strike a deal with the devil, Agent Ward himself (and Agent 33).
Although Ward is technically no longer Hydra, he produces the brainwashed Bakshi (Simon Kassianides), who is able to arrange a meeting with Dr List (Henry Goodman), a compatriot of Strucker's, who has small supporting roles in Age Of Ultron and The Winter Soldier.
However, Bakshi decides to use Deathlok - posing as his bodyguard - as leverage to get back in favour with the Hydra higher-ups, much to the annoyance of Coulson.
This, though, was Ward's plan all along and is just a small element of this episode's wonderfully scripted labyrinth of plots, counter-plots, double-crosses and superb array of misdirection, misinformation and misunderstandings.
Meanwhile, over at the 'real' S.H.I.E.L.D., Simmons confides in May that the 'toolbox' she has been been working to unlock is a fake and that Fitz left with the real one. May is pissed, but throws Fitz under the bus, rather than Simmons, and then asks Simmons if it's possible to hack into Deathlok's eye camera, to see if they can find Coulson.
At the Inhuman refuge, Skye learns that her mum is going to send Cal away - as he 'doesn't belong there'. Skye persuades Jiaying to allow her to accompany Cal to Milwaukee (his home town), to help lessen the blow of having his family taken away from him again.
Naturally, this doesn't go according to plan - especially as Hydra has found a way to track Gordon's teleportation schtick - and the end result is a multi-sided shoot-out/superpowered slugfest in an abandoned office building, as both Hydra and Team Coulson close in on Skye.
Frenemy Of My Enemy took its time to find its feet, with some scenes dragging unnecessarily (especially some of the 'bonding' between Skye and Cal), but it all built up to a brilliantly woven climax that was Agents Of S.H.I.E.L.D. doing what it does best: the murky, distrustful world of espionage in the Marvel Cinematic Universe.