Some time has passed since the events at the end of Season Two and Inhumans are starting to "wake up" around the world, thanks to the Terrigen released in to the food chain.
When possible S.H.I.E.L.D. is swooping in to extract these new 'gifted individuals' before a mysterious, black ops team can snatch them.
While Skye - now going by her birth name of Daisy - and Mack do the heavy lifting in the retrieval squad, a casually-dressed Coulson (now sporting a cybernetic hand) spies on the leader of the black ops team, Rosalind Price (Constance Zimmer).
The latest Inhuman that S.H.I.E.L.D. rescues, Joey Gutierrez (Juan Pablo Raba), has a hard time accepting the new life that Daisy and Mack spell out for him, so they decide to try and get Lincoln to come in and explain matters to him.
Lincoln has turned his back on S.H.I.E.L.D. and is working as a doctor, but when Daisy and Mack approach him, they are all attacked by a monstrous creature that we know from pre-publicity material is Lash (Matthew Willig).
Meanwhile, with May on extended leave, and Hunter and Bobbi dancing round each other, Fitz is single-mindedly chasing clues to Simmons' fate, after she was absorbed into the monolith.
The rest of the team believe she is dead, but Fitz refuses to accept this.
Her actual fate is revealed in the episode's coda, which - thanks to the fact that we're seeing this about three months after it aired in the States - we already knew: she's on a barren alien planet!
It's great to have Agents of S.H.I.E.L.D. back - albeit later than I would have liked - and Laws Of Nature burst out of the starting blocks, not giving us a much time to take a breath.
The episode clearly had a lot to get in place for the rest of the season, so was sparse on the usual witty banter (although it's still there) and heavy on plot.
It also firmly reestablished the show in the larger Marvel Cinematic Universe with references to events in Avengers: Age Of Ultron, Captain America: The Winter Soldier, Thor: The Dark World, and even Ant-Man.